OpenLB
Open Library of Bioscience

Souvik Roy, Robert D Kina, Nathaniel N Koloian, Daniah Zubair, Alexis A Brecht, Andrew M Lipchik, Andrew D Berti

J Med Microbiol. Sep, 2025.74(9): Print doi: 10.1099/jmm.0.002077

PMID: 40960864

Contemporary pharmaceutical design often incorporates functional groups to improve the pharmacokinetic/pharmacodynamic profile of a desired active chemical entity. These compounds are known as prodrugs. While prodrug enhancements may improve a medication's clinical utility, they often limit the abil...

Emi Tanaka, Takeaki Wajima, Sonoe Hirano, Shoji Seyama, Hidemasa Nakaminami, Kei-Ichi Uchiya

J Med Microbiol. Sep, 2025.74(9): Print doi: 10.1099/jmm.0.002075

PMID: 40955639

Zehua Su, Jiaqi Lin, Xuejiao Zeng, Xin Li, Qianhao Hou, Qing Wang, Chunzheng Liu, Jiawen Qin, Yuling Li, Jinyuan Zhang, Xiangrui Wang, Shuwen Qian, Lijun Liao

J Med Microbiol. Sep, 2025.74(9): Print doi: 10.1099/jmm.0.002038

PMID: 40960868

This study centres on how coronavirus disease 2019 (COVID-19) disrupts the intestinal microbiota and amplifies systemic inflammation and evaluates ozone water enemas as a strategy to restore gut microbial balance and activate the SIRT1 (silent information regulator of transcription 1)-Nrf2 (nuclear...

Ioana D Olaru, Sarah Schoeler, Frieder Schaumburg

J Med Microbiol. Sep, 2024.73(9): Print doi: 10.1099/jmm.0.001890

PMID: 39292220

The European Committee on Antimicrobial Susceptibility Testing (EUCAST) specifies the agar depth (4±0.5 mm) when performing antimicrobial susceptibility testing (AST). Since the infrastructure to produce standardized agar may be lacking in settings with limited resources, we wanted to examine to wh...

Jielin Qin, Han Yang, Zhiming Shan, Lingzhi Jiang, Qingxian Zhang

J Med Microbiol. Oct, 2021.70(10): Print doi: 10.1099/jmm.0.001434

PMID: 34633919

Antifungal drugs have already been established as an effective treatment option for infections, but there is no universal consensus on the ideal target for clinical efficacy and safety of antifungal drugs for the treatment of infections. Few studies have directly compared the efficacies of antifun...

Priksha Thakur, Narinder Kaur, Shubham Chauhan, Reham Abdelmonem, Richard Donkor Amponsah

J Med Microbiol. Jul, 2025.74(7): Print doi: 10.1099/jmm.0.002039

PMID: 40658603

Urinary tract infections (UTIs) are a significant global health concern, with being the predominant pathogen responsible for uncomplicated and complicated cases. Fosfomycin has emerged as a promising oral treatment option for multidrug-resistant UTIs, particularly those caused by extended-spectrum...

Priksha Thakur, Narinder Kaur, Shubham Chauhan, Reham Abdelmonem, Richard Donkor Amponsah

J Med Microbiol. Sep, 2025.74(9): Print doi: 10.1099/jmm.0.002076

PMID: 40952908

Yingzhe Wang, Yingting Huang, Wei Long, Shigan Ye, Yuan Deng, Sanquan Zhang, Huanli Wang, Xiaoliang Zhu

J Med Microbiol. Sep, 2025.74(9): Print doi: 10.1099/jmm.0.002060

PMID: 40938764

Azoles are extensively employed as clinical antifungal agents; however, their long-term and widespread application contributed to the progressive emergence of azole resistance. A significant increase in infections caused by azole-resistant highlights the need for novel therapeutic strategies. The ...

Alexandre Giraud-Gatineau, Kouessi Dagbo, Helena Pětrošová, Catherine Werts, Fréderic J Veyrier, Mathieu Picardeau

J Med Microbiol. Sep, 2025.74(9): Print doi: 10.1099/jmm.0.002059

PMID: 40938636

Leptospirosis is a re-emerging zoonosis caused by a diverse range of pathogenic , which are divided into species, serogroups and serovars. Although advances in genomics have recently refined species classification, serotyping, which is based on the antigenic variability of lipopolysaccharides O-anti...

Emi Tanaka, Takeaki Wajima, Sonoe Hirano, Shoji Seyama, Hidemasa Nakaminami, Kei-Ichi Uchiya

J Med Microbiol. Oct, 2024.73(10): Print doi: 10.1099/jmm.0.001904

PMID: 39360813

Reports of β-lactamase-producing are increasing worldwide.. This study aimed to elucidate the molecular characteristics and evolution of β-lactamase-producing . A total of 159 clinical isolates were characterized using multi-locus sequence typing. Antimicrobial resistance genes and integrative and...